Diwakar Turaga

This study identifies distinct cellular processes in end-stage pediatric HCM using single-nucleus RNA sequencing, highlighting activated fibroblasts and stressed cardiomyocytes.

The paper presents the single-nucleus transcriptome of a systemic right ventricle from a patient with congenitally corrected transposition of great arteries, identifying increased insulin and angiogenesis signaling as potential beneficial adaptations to pressure overload.

This study shows that human iPSC-derived organoids can model the cooperative development of cardiac and gut tissues through paracrine signaling.