Xiao Li

This study identifies SARS-CoV-2 NSP13 as a suppressor of Hippo-YAP signaling by interacting with TEAD and remodeling chromatin to inhibit YAP transcriptional activity.

This study identifies distinct cellular processes in end-stage pediatric HCM using single-nucleus RNA sequencing, highlighting activated fibroblasts and stressed cardiomyocytes.

The paper shows that Nup98 nucleoporins use phase separation to mobilize heterochromatic repair sites and exclude Rad51, promoting homologous recombination and genome integrity.

The paper presents the single-nucleus transcriptome of a systemic right ventricle from a patient with congenitally corrected transposition of great arteries, identifying increased insulin and angiogenesis signaling as potential beneficial adaptations to pressure overload.

This study shows that Hippo-deficient cardiac fibroblasts differentiate into osteochondroprogenitors and interact with macrophages, promoting fibrosis through CSF1 signaling.

The paper shows that active retrotransposons produce siRNAs that maintain pericentromeric heterochromatin, ensuring stable genetic inheritance in Drosophila cells.

SECNVs simulates copy number variants and whole-exome sequences from reference genomes to improve comparison of detection methods.

The paper presents a single-cell transcriptomic analysis of nucleated cells in umbilical cord blood, identifying cell types, subpopulations, and transcriptional programs that may impact transplant outcomes.