Prabu Paramasivam

Exercise Conditioning Enhances Insulin Sensitivity with Metabolic and Glycemic Control Driven by Hepatic Silencing of HMGB1 in Type 2 Diabetic Mice

This study shows that exercise improves insulin sensitivity in T2D mice by reducing HMGB1 levels in the liver, leading to better glycemic control and metabolic health.

Targeting CRM1-HMGB1 Nuclear Translocation in Type 2 Diabetes-Driven Metabolic Dysfunction Associated Steatotic Liver Disease

This study investigates the role of CRM1/HMGB1 nuclear translocation in T2D-driven MASLD and shows that inhibiting this pathway reduces HMGB1 release in T2D-NASH.

High-Intensive Interval Training Decreases Circulating HMGB1 in Insulin Resistant Patients; Plasma Lipidomics Identifies Associated Cardiometabolic Benefits

This study shows that high-intensity interval training reduces HMGB1 and improves cardiometabolic markers in insulin-resistant individuals through lipidomic and cytokine analyses.

Interplay of host regulatory network on SARS-CoV-2 binding and replication machinery

The paper investigates the host regulatory network's role in SARS-CoV-2 binding and replication, identifying key hubs and miRNAs that could be therapeutic targets.