Jinhua Chi

Akkermansia muciniphila prevents cadmium-induced cognitive impairment through gut microbiome mediated mechanisms

This study shows that Akkermansia muciniphila prevents cadmium-induced cognitive impairment in mice through gut microbiome and metabolite mechanisms, not by reducing brain cadmium levels.

Proteome-wide reverse molecular docking reveals folic acid receptor as a mediator of PFAS-induced neurodevelopmental toxicity

This study identifies folic acid receptor beta as a mediator of PFAS-induced neurodevelopmental toxicity using zebrafish models and reverse molecular docking.

O-GlcNAcylation regulates PPAR-driven metabolic programming in intestinal stem cells

This study shows that O-GlcNAcylation regulates PPAR-driven metabolic programming in intestinal stem cells by linking dietary metabolism to transcriptional control.

Erythropoietin Mediates Glycerophospholipid Remodeling During Human Early Erythropoiesis

This study identifies erythropoietin's role in regulating glycerophospholipid metabolism during human erythropoiesis using single-cell transcriptomics and lipidomics.

Glucose and Oxygen Metabolism Coordinate Human Cortical Developmental Decisions

This study shows that physiologic glucose and oxygen levels influence human cortical development by altering metabolic states and cell fate decisions in organoids.

In vivo exposure of mixed microplastic particles in mice and its impacts on the murine gut microbiome and metabolome

This study shows that microplastic exposure alters gut microbiome composition and serum metabolome in mice, with sex-specific and dose-dependent effects.

Butyrate rescues chlorpyrifos-induced social deficits through inhibition of class I histone deacetylases

The paper shows that butyrate rescues CPF-induced social deficits in zebrafish by inhibiting class I HDACs, linking CPF exposure to gut microbiome, metabolome, and epigenetic changes.

Exercise Conditioning Enhances Insulin Sensitivity with Metabolic and Glycemic Control Driven by Hepatic Silencing of HMGB1 in Type 2 Diabetic Mice

This study shows that exercise improves insulin sensitivity in T2D mice by reducing HMGB1 levels in the liver, leading to better glycemic control and metabolic health.

Maternal dietary deficiencies in folic acid and choline change metabolites levels in offspring after ischemic stroke

This study examines how maternal dietary deficiencies in folic acid and choline affect offspring metabolite levels after ischemic stroke, showing sex-specific differences.