Accurate detection of metagenomic strain-level associations using average nucleotide identity with StrainSpy
Sudaraka Mallawaarachchi, Kshitij Tandon, Nikhil Rajan…·Gerry Q. Tonkin‐Hill
StrainSpy fits zero-inflated beta mixed models to containment ANI, reaching >98% simulated sensitivity versus ~79% for logistic regression and detecting colorectal-cancer E. coli strain shifts.