Nanobodies recognizing conserved hidden clefts of all SARS-CoV-2 spike variants
Ryota Maeda, Junso Fujita, Yoshinobu Konishi, Yasuhiro Kazuma, Hiroyuki Yamazaki, Itsuki Anzai, Tokiko Watanabe, Keishi Yamaguchi, Kazuki Kasai, Kayoko Nagata, Yutaro Yamaoka, Kei Miyakawa, Akihide Ryo, Kotaro Shirakawa, Kei Sato, , Akifumi Takaori‐Kondo
The paper presents nine alpaca nanobodies that recognize conserved hidden epitopes on SARS-CoV-2 spike proteins across variants and maintain neutralizing activity against escape mutations.
Communications Biology · Jul 6, 2022Peer-reviewedMolecular Biology