A Protein Language Model for Exploring Viral Fitness Landscapes
Jumpei Ito, Adam Patrick Strange, Wei Liu, Gustav Joas, Spyros Lytras, Keita Matsuno, Naganori Nao, Hirofumi Sawa, Keita Mizuma, Isshu Kojima, Jingshu Li, Tomoya Tsubo, Shinya Tanaka, Masumi Tsuda, Lei Wang, , Kei Sato
This paper introduces CoVFit, a protein language model that predicts SARS-CoV-2 variant fitness using spike protein sequences, identifying fitness-enhancing mutations and predicting emerging variants.
Nature Communications · May 13, 2025Peer-reviewedMicrobiology