Wadih Arap

Combinational adjuvants delivered by ink-jet potentiate naked mRNA vaccines for robust protection against infectious diseases

This study identifies a combination of adjuvants that enhance the immunogenicity of naked mRNA vaccines delivered by jet-injection, achieving protection against SARS-CoV-2 and influenza with reduced reactogenicity.

An AI/ML-modeled structural atlas of the human protein interactome with functional and cancer-focused networks

The paper uses Boltz-2 to predict structural models of human protein interactions and identifies functional and cancer-related networks.

High-throughput prediction of peptide structural conformations with AlphaFold2

This study evaluates AlphaFold2's ability to predict peptide structural conformations using NMR data, finding varying accuracy with RMSD under 2.5 Å and RMSF under 1.5 Å.

Generative artificial intelligence performs rudimentary structural biology modeling

This study shows that GPT-4 can generate 3D protein structures and analyze ligand-protein interactions with atomic-scale accuracy, though it has limitations with complex models.

Genomic Landscape of Lymphatic Malformations: A Case Series and Response to the PI3Kα Inhibitor Alpelisib in an N-of-One Clinical Trial

This paper reports the genomic profile of lymphatic malformations, identifies PIK3CA and NRAS mutations, and shows a response to the PI3K inhibitor alpelisib in a personalized trial.