Scott A. Ness

Gene-Expression Programs in Salivary Gland Adenoid Cystic Carcinoma Analyzed Using Single-Cell and Spatial Transcriptomics

This study uses single-cell and spatial transcriptomics to analyze gene expression in salivary gland adenoid cystic carcinoma, revealing tumor heterogeneity, molecular interactions, and potential therapeutic targets.

Identification of host lncRNAs that impact Venezuelan equine encephalitis virus replication

The paper identifies lncRNAs that influence VEEV replication in mouse astrocytes, showing that suppressing Snhg15 increases viral replication and affects antiviral gene expression.

Genomic Landscape of Lymphatic Malformations: A Case Series and Response to the PI3Kα Inhibitor Alpelisib in an N-of-One Clinical Trial

This paper reports the genomic profile of lymphatic malformations, identifies PIK3CA and NRAS mutations, and shows a response to the PI3K inhibitor alpelisib in a personalized trial.

Two-Step Mixed Model Approach to Analyzing Differential Alternative RNA Splicing

This paper develops a two-step mixed model approach to detect and analyze differential alternative RNA splicing and gene expression, showing improved performance over existing methods.