Semenogelin-1 Inhibition of Mouse Sperm Hyperactivation Reveals Two Functional Domains Modulating CatSper Channel
Noemia Aparecida Partelli Mariani, Natália C. M. Santos, Juliana J. Andrade, Alexandre Dorth de Andrade, Beatriz Rezende, Tomás J. Steeman, Analia G. Novero, Jose Carlos De Lima-Jr, Giulia Calderaro, Ana Clara F. Themer, Hélio Kushima, Mariano Gabriel Buffone, Darío Krapf, Polina V. Lishko, Erick J. R. Silva
This study identifies two functional domains in SEMG1 that inhibit sperm hyperactivation by suppressing CatSper channel activity, providing insights for non-hormonal male contraception.
bioRxiv · Sep 5, 2025 · PreprintPhysiology