Viroporin activity from rotavirus nonstructural protein 4 induces intercellular calcium waves that contribute to pathogenesis
John Thomas Gebert, Francesca J. Scribano, Kristen A. Engevik, Ethan M. Huleatt, Michael R. Eledge, Lauren E. Dorn, Asha A. Philip, Takahiro Kawagishi, Harry B. Greenberg, John T. Patton, Joseph M. Hyser
This study identifies NSP4 as a viroporin that induces intercellular calcium waves, contributing to rotavirus virulence through innate immune activation and disease severity.
Science Advances · Jan 17, 2025Peer-reviewedMicrobiology