Joseph M. Hyser

This study identifies CaV1.2 as a Ca2+ influx channel that interacts with KCa1.1 to regulate invasiveness of RA-FLS through Ca2+ homeostasis.

This paper develops fluorescent and affinity-tagged rotavirus NSP4 variants using reverse genetics to study its function during infection.

This study shows that BTP2 inhibits Tulane virus and human norovirus replication by targeting structural proteins, not through SOCE, and establishes a system for antiviral screening.

This study identifies NSP4 as a viroporin that induces intercellular calcium waves, contributing to rotavirus virulence through innate immune activation and disease severity.

This study shows that blocking P2Y1 receptors reduces rotavirus-induced diarrhea and viral shedding in mice, suggesting P2Y1 signaling promotes disease.

This paper develops a bioengineered probiotic to deliver a Kv1.3 channel blocker peptide for treating rheumatoid arthritis, showing efficacy in reducing inflammation and joint damage in rat models.