The paper examines how regional brain architecture similarity to sex-typical young adult patterns correlates with neuroinflammation and depression in later adulthood using longitudinal data.

bioRxiv · Oct 6, 2026 · PreprintNeuroscience

Central nervous system-derived inflammasome cytokines drive neuroglial injury and cerebral oedema in viral encephalitis, despite corticosteroid therapy

Franklyn Nkongho Egbe, Cordelia Dunai, Claire Hetherington, Sarah A. Boardman, Laura Bricio-Moreno, Bethany Facer, Cory Hooper, David Haw, Alexandra–Chloé Villani, Luca Lenzi, Sam T. Haldenby, Sally O. Oswald, Steve Patterson, Evelyn Kurt-Jones, Andrew David Luster, , Benedict Daniel Michael

This study identifies IL-1 and IL-6 as key drivers of neuroinflammation in HSV encephalitis, showing they are not reduced by corticosteroids and are associated with poor outcomes.

bioRxiv · Oct 10, 2025 · PreprintNeuroscience

Proteome-wide Mendelian randomization identifies causal links between blood proteins and severe COVID-19

Alish Palmos, Vincent Millischer, David Krishna Menon, Timothy R. Nicholson, Leonie S. Taams, Benedict Daniel Michael, Geraint J. Sunderland, Michael John Griffiths, Christopher Hübel, Gerome D. Breen

This study uses proteome-wide Mendelian randomization to identify blood proteins causally linked to severe COVID-19, finding several proteins associated with increased or decreased risk.

PLoS Genetics · Mar 3, 2022Peer-reviewedGenetic & Genomic Medicine