Leonie S. Taams

This study identifies LIF as a key pro-algesic cytokine in arthritis-related pain, showing its role in neuronal signalling and pain-like behaviours in human and mouse models.

The paper identifies a broader pathogenic T cell receptor motif linked to HLA-B*27-associated autoimmune diseases and shows these T cells express a Type 17 program.

The paper identifies shared CD8+ T-cell clones between skin and joint in psoriatic arthritis, suggesting clonal migration and coordinated inflammation.

This paper identifies Pdgfrb+ fibroblast and mural cells as contributors to neuropathic pain by showing their increased numbers and expression of pro-algesic mediators in a mouse model.

This study shows JAK inhibitors block RA synovial fluid-induced sensory neuron activation by inhibiting STAT3 phosphorylation and pain gene expression.

The paper investigates the effects of inflammatory soup on sensory neuron excitability using human and mouse models, finding minimal changes and suggesting that in vitro modeling of peripheral sensitization is complex.

The paper profiles lipidomes of neutrophil-derived extracellular vesicles in joint inflammation and finds species-specific lipid changes linked to inflammatory conditions.

This study uses proteome-wide Mendelian randomization to identify blood proteins causally linked to severe COVID-19, finding several proteins associated with increased or decreased risk.

This study shows that TNF-α activated fibroblast-like synoviocytes sensitize knee neurons in vitro, contributing to inflammatory pain in arthritis.