Christopher Hübel

This study identifies genetic differences between fear-based anxiety disorders and generalised anxiety disorder using GWAS, finding partial genetic distinction and shared liability to internalising psychopathology.

LDSC++ improves heritability and genetic correlation estimation in multivariate GWAS by enhancing LD score regression with segmented regression and better handling of shared genetic variants and imputation quality.

The paper examines diagnostic transitions and remission in eating disorders using polygenic scores in a Danish cohort, finding significant genetic associations with these outcomes.

This study investigates the genetic relationship between depression symptoms and Alzheimer's disease using GWAS and finds significant genetic correlations but no causal link, suggesting proxy cases may drive the overlap.

This study examines the association between polygenic scores for anorexia nervosa and BMI with growth trajectories over 20 years in children, finding sex-specific effects and potential risk interactions.

This study uses proteome-wide Mendelian randomization to identify blood proteins causally linked to severe COVID-19, finding several proteins associated with increased or decreased risk.

The paper investigates genetic associations between eating disorder symptoms and polygenic scores for psychiatric, metabolic, and anthropometric traits in adolescents.

This study uses multiple depression measures to improve the validity of Major Depressive Disorder cases in the UK Biobank, finding increased genetic contribution with more measures.

The paper examines sex-differentiated genetic effects across neuropsychiatric and behavioral traits using GWAS summary statistics and finds small, polygenic sex differences with enriched neuron-related genes.

This study identifies cell types associated with brain complex traits using GWAS and single-cell transcriptomics, revealing novel roles for oligodendrocytes in Parkinson's disease.

The paper investigates the association between BMI polygenic scores and disordered eating behaviors in a general population cohort, finding a positive link mediated by BMI.

The paper estimates genetic correlations between eating disorder and substance-use-related phenotypes using GWAS data, finding both positive and negative associations.

This study identifies five novel genome-wide significant loci for anxiety disorders and finds significant genetic correlations with depression, insomnia, and coronary artery disease.

This study investigates the genetic and environmental links between major depressive disorder and traumatic experiences using UK Biobank data, finding shared genetic factors and distinct patterns in trauma-exposed individuals.

This paper uses GWAS data from MDD to identify potential drug targets and repurposing opportunities by analyzing drug-target networks and gene expression effects.

The paper constructs a phenome map using genetic correlations from 465 GWAS to cluster human traits and identify pathway enrichments.