The Q226H Mutation in Avian H5N1 Hemagglutinin Mediates a Path towards Structural Adaptation in Humans
Ross A. Edwards, Oluwafemi F. Adu, Egor P. Tchesnokov, Dana Kocíncová, Emma Woolner, Zoe Turner, Duong T. Bui, Lara K. Mahal, Nathan J. Zelyas, John S. Klassen, Andrei P. Drabovich, Kalyan Das, Matthias Götte
The paper shows that the Q226H mutation in H5N1 hemagglutinin allows binding to human-type a2-6 sialic acid receptors, suggesting a path towards human adaptation.
bioRxiv · May 26, 2026 · PreprintImmunology