Matthias Götte

This study identifies a two-pronged mechanism by which CMX521 inhibits SARS-CoV-2 RNA-dependent RNA polymerase through biochemical assays and single-molecule techniques.

This study identifies non-nucleoside inhibitors of EV-D68 3D polymerase through crystallographic fragment and high-throughput screening, revealing potential drug targets and lead compounds.

This study investigates the antiviral activity and mechanism of 4'-fluoroadenosine against viral and host polymerases, showing broad-spectrum inhibition and potential for drug development.

The paper shows that the Q226H mutation in H5N1 hemagglutinin allows binding to human-type a2-6 sialic acid receptors, suggesting a path towards human adaptation.

This study investigates remdesivir incorporation by SARS-CoV-2 RNA polymerase and the S759A resistance mechanism using enzymatic assays, mass spectrometry, and cryo-EM.

The paper shows that the SARS-CoV-2 polymerase core RTC undergoes a conformational change after RNA binding to become elongation-competent, which is essential for viral RNA synthesis.

This study uses a single-molecule assay to analyze the binding dynamics of SARS-CoV-2 polymerase complex subunits with RNA, revealing differences in binding stability between co-expressed and reconstituted complexes and the effects of inhibitors.

This study investigates how a 4'-cyano modified nucleotide analog inhibits RNA polymerases of respiratory viruses, showing varying efficiency across different viral species.