The structurally conserved TELR region on shelterin protein TPP1 is essential for telomerase processivity but not recruitment
Ranjodh Sandhu, Madhav B Sharma, Derek Wei, Lifeng Xu
This study identifies TPP1 mutations that impair telomerase processivity without affecting recruitment, showing processivity is critical for telomere length homeostasis.
Proceedings of the National Academy of Sciences · Jul 19, 2021Peer-reviewedGenetics