GeneticsProceedings of the National Academy of SciencesPeer-reviewed
The structurally conserved TELR region on shelterin protein TPP1 is essential for telomerase processivity but not recruitment
Ranjodh Sandhu, Madhav B Sharma, Derek Wei, Lifeng Xu
This study identifies TPP1 mutations that impair telomerase processivity without affecting recruitment, showing processivity is critical for telomere length homeostasis.
10 citations