Author

Carlos Renato Machado

Universidade Federal de Minas GeraisORCID 0000-0002-8724-3165Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Daniela de Laet Souza· 2 shared Glória Regina FrancoiD· 2 shared Alessandro M. VaraniiD· 1 shared Ana María Mejía‐JaramilloiD· 1 shared Andréa Mara MacedoiD· 1 shared Carlos A. RosaiD· 1 shared Dafne de Oliveira VianeiiD· 1 shared Daniela Ferreira ChameiD· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBioinformatics

Daniela de Laet Souza

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3 papers

Recent·Most cited

BioinformaticsbioRxivPreprintSep 29, 2025

The peptide LyeTx I mnΔK induces transcriptomic reprogramming in a novel Multidrug-resistant Acinetobacter baumannii

Frederico Gabriel de Carvalho Oliveira, Katharina O. Barros, Dafne de Oliveira Vianei…·Glória Regina Franco

This study characterizes a new multidrug-resistant Acinetobacter baumannii isolate and evaluates the transcriptomic effects of a synthetic antimicrobial peptide in combination with meropenem.

DOI 10.1101/2025.09.29.679197

humanwhole-genome sequencing

Molecular BiologybioRxivPreprintSep 8, 2025

The role of the Trypanosoma cruzi enzyme L-threonine 3-dehydrogenase in combating stressful environments

Ana María Mejía‐Jaramillo, Paola García‐Huertas, Carlos Renato Machado, Omar Triana‐Chávez

This study shows that overexpressing L-threonine 3-dehydrogenase (TDH) in Trypanosoma cruzi increases survival under oxidative stress and drug exposure, and improves infection capacity.

DOI 10.1101/2025.09.08.674805

experimental assay

BioinformaticsFrontiers in GeneticsPeer-reviewedSep 3, 2020

Differential modulation of mouse heart gene expression by infection with two Trypanosoma cruzi strains: a transcriptome analysis

Tiago B. R. Castro, Maria Cecília Campos Canesso, Mariana Boroni…·Glória Regina Franco

This study compares gene expression changes in mouse hearts infected with two T. cruzi strains, showing distinct immune and metabolic effects.

14 citations

mousebulk RNA-seq