Tiago B. R. Castro

Weaning imprints a hybrid cytotoxic-regulatory identity on intestinal CD4+ T lymphocytes

This study tracks intestinal CD4+ T cells from suckling to adulthood, showing they adopt a transient cytotoxic-regulatory state at weaning, influenced by microbiota and early-life commensals.

Replaying germinal center evolution on a quantified affinity landscape

Across 119 monoclonal germinal centers, B cell affinity rises reliably despite divergent phylogenies. Selection is noisy but persistent; mutability limits exploration. A DMS-based landscape shows saturating fitness and survivorship biases.

Tissue-specific clonal selection and differentiation of CD4+ T cells during infection

This study uses TRACK mice to show tissue-specific clonal selection and differentiation of CD4+ T cells during influenza infection, revealing organ-specific transcriptional programs and memory formation patterns.

Differential modulation of mouse heart gene expression by infection with two Trypanosoma cruzi strains: a transcriptome analysis

This study compares gene expression changes in mouse hearts infected with two T. cruzi strains, showing distinct immune and metabolic effects.

Microbes modulate sympathetic neurons via a gut-brain circuit

The paper shows that gut microbes influence sympathetic neurons through a metabolite-mediated gut-brain circuit, with butyrate suppressing sympathetic activity.