Cancer BiologybioRxivPreprint
Gallium induces cytotoxicity through disruption of DNA synthesis rather than ferroptosis
Jingzhi Fan, Annija Vaska, Xiping Jiang, Kristaps Klavins
This study identifies gallium's cytotoxic mechanism in osteosarcoma as disrupting DNA synthesis via ribonucleotide reductase inhibition, not ferroptosis, and shows synergy with cisplatin.
DOI 10.64898/2026.04.01.715544