Kristaps Klavins

This study shows N-acetylcysteine's antibacterial activity against S. aureus depends on pH, with neutral pH reducing activity and altering metabolism without inhibiting growth.

This study identifies gallium's cytotoxic mechanism in osteosarcoma as disrupting DNA synthesis via ribonucleotide reductase inhibition, not ferroptosis, and shows synergy with cisplatin.

This study shows that fetal bovine serum (FBS) significantly affects human neutrophil behavior in culture, unlike collagen coatings, highlighting the need for alternative models in biomaterial studies.

This study identifies purine nucleobases as immunometabolites that enhance CD8+ T cell effector function by enabling a metabolic switch from de novo synthesis to salvage pathway.

The paper systematically evaluates the metabolic and transcriptional effects of SLC superfamily members, identifying new substrates and functional groups.

The paper identifies a non-enzymatic role of NUDT5 in repressing purine de novo synthesis by scaffolding PPAT, with implications for cancer treatment and MTHFD1 deficiency.