Anna M. Kietrys

Reversible RNA Acylating Reagents with Nitro Reduction Strategy

This study develops reversible RNA acylating reagents using a nitro reduction strategy and demonstrates their ability to modulate RNA function and translational activity in vitro and in cells.

The Shape of Control: How Going in Circles Keeps RNA Catalytically Switched On

This study shows that G-quadruplex formation regulates RNA catalytic activity, with linear RNA (linM1) being more prone to it than circular RNA (circM1).

Unlocking efficiency: Native circular RNA surpass linear isoforms in RNase P activity

The paper identifies circular RNA isoforms of RNase P in bacteria, fungi, and human cells, showing improved stability and distinct protein interactions compared to linear forms.

RNA functional control by hydrolysis reversible acylation

This paper introduces EST1A, a hydrolysis-responsive 2'-OH acylating reagent that enables reversible control of RNA function through esterase-mediated deacylation, showing cell-selective activation in different cell lines.