CD62L-selected umbilical cord blood universal CAR T cells
Christos Georgiadis, Lauren E. Nickolay, Farhatullah Syed, Hong Zhan, Soragia Athina Gkazi, Annie Etuk, Ulrike Mock, Roland Preece, Piotr Cuber, Stuart Paul Adams, Giorgio Ottaviano, Waseem Qasim
This paper describes the production of CD62L-selected UCB-derived CAR T cells using machine-based manufacturing, showing high CAR19 expression and anti-leukaemic activity comparable to peripheral blood-derived CAR T cells.
bioRxiv · Jan 18, 2024 · PreprintMolecular Biology