Roland Preece

This study compares non-viral and lentiviral CAR-T cell manufacturing, finding comparable in vitro function but lower efficacy and increased exhaustion in non-viral CAR20-T cells in humanised mouse models.

This paper develops base-edited CAR T cells targeting CD38 to create an off-the-shelf immunotherapy that avoids allo-rejection and shows anti-leukemic activity.

This study shows that base edited universal donor CAR T cells targeting multiple antigens can inhibit AML in mice, with combination therapies needed for heterogeneous disease.

This paper describes the production of CD62L-selected UCB-derived CAR T cells using machine-based manufacturing, showing high CAR19 expression and anti-leukaemic activity comparable to peripheral blood-derived CAR T cells.

This study develops base-edited CAR T cells to overcome fratricide by removing shared antigens, showing enhanced cytotoxicity against T cell malignancies.