Stuart Paul Adams

The paper examines the transcriptional evolution of myeloid leukaemia in Down syndrome by analyzing single-cell RNA sequencing data from patient samples and fetal tissues.

This paper develops and validates a crude lysate ddPCR assay for accurate absolute quantification of rare genes like TRECs from limited clinical samples, eliminating DNA extraction and improving performance over standard ddPCR.

This paper describes the production of CD62L-selected UCB-derived CAR T cells using machine-based manufacturing, showing high CAR19 expression and anti-leukaemic activity comparable to peripheral blood-derived CAR T cells.