Structural basis of ZP2-targeted immunocontraception
Elisa Dioguardi, Alena Stsiapanava, Eileen Fahrenkamp, Ling Han, Daniele de Sanctis, José Inzunza, Luca Jovine
This study shows that an IE3-derived scFV blocks fertilization by binding ZP2 and determines the structural basis of this interaction, offering insights for non-hormonal immunocontraceptives.
Proceedings of the National Academy of Sciences · Apr 11, 2025Peer-reviewedBiophysics