Keara M. Lane

This study investigates the role of H-NS repression in virulence gene expression and pathogen adaptation by using a Salmonella strain with reduced H-NS DNA-binding affinity.

The paper shows that Salmonella Typhimurium uses switch-like SPI-2 gene expression to probabilistically adapt to uncertain intracellular environments through phenotypic heterogeneity.

This study shows that expressing the SPI-2 master regulator ssrB imposes environment-specific growth and fitness costs in Salmonella, independent of the T3SS.

This study shows Salmonella Typhimurium sensitizes macrophages to respond to IL-4, leading to anti-inflammatory polarization through a two-signal model.