Gary P. Wormser

This study uses multiomic analysis to identify compartmentalized immune responses and tissue-vascular signatures in Lyme disease, linking local immune processes to systemic symptoms.

The paper compares transcriptomic responses to larval Ixodes scapularis bites in Peromyscus leucopus, Mus musculus, and humans, finding distinct immune activation patterns.

This study uses long-read assemblies to show that genetic modules across multiple plasmids organize Borrelia burgdorferi strain variation and influence virulence in Lyme disease.

The paper identifies 10 blood proteins with altered serum levels in early Lyme disease patients, developing a 10-protein panel for potential diagnostic use.