This study investigates the role of RNA m6A modification in aneuploid Drosophila, showing its impact on gene regulation and developmental abnormalities through interactions with the MSL complex and dosage compensation mechanisms.

eLife · Jan 24, 2025Peer-reviewedGenomics

Inverse and Proportional trans Modulation of Gene Expression in Human Aneuploidies

Shuai Zhang, Ruixue Wang, Ludan Zhang, James A. Birchler, Lin Sun

The paper analyzes transcriptome data from human aneuploidies to show inverse or proportional trans-modulation of genes on unvaried chromosomes and compensation on varied chromosomes, with differences observed between autosomal and sex chromosome aneuploidies.

Genes · May 17, 2024Peer-reviewedGenetics

Whole exome sequencing identifies genes associated with non-obstructive azoospermia

Hongguo Zhang, Hui Huang, Xinyue Zhang, Jia Li, Yuting Jiang, Leilei Li, Jing Zhao, Jing He, Mucheng Chen, Ruixue Wang, Jing Wu, Zhiyu Peng, Ruizhi Liu

The paper identifies five novel genes associated with non-obstructive azoospermia through whole exome sequencing and linkage analysis in a case-control study.

Frontiers in Genetics · Apr 13, 2022Peer-reviewedGenetic & Genomic Medicine