Jing Zhao

Haplotype-resolved genome assembly of barberry reveals structural divergence and allele-specific expression during infection by wheat stripe rust pathogen

This study presents a haplotype-resolved genome of barberry and shows how haplotype divergence and allele-specific expression contribute to transcriptional responses during wheat stripe rust infection.

Deep-learning-enabled multi-omics analyses for prediction of future metastasis in cancer

This paper introduces EmitGCL, a deep-learning framework that predicts future metastasis in cancer with high accuracy, identifies biomarkers, and validates therapeutic targets.

Intracellular Delivery of Peptides and Proteins with an Engineered Membrane Translocation Domain

This paper develops an engineered membrane translocation domain (MTD4) that enables efficient intracellular delivery of peptides and proteins, demonstrating its effectiveness in vitro and in vivo.

The in vivo inhibitory function of the MHC-I alpha3 domain/CD8alpha interaction

This study identifies the MHC-I alpha3 domain-CD8 interaction as an inhibitory pathway that restrains CD8+ T-cell activation and maintains tolerance in vivo.

Formalized scientific methodology enables rigorous AI-conducted research across domains

The paper formalizes scientific methodology as a protocol for AI research, showing it produces auditable, evidence-backed outputs across domains and recovers known biological signals in genomics.

Rapid ecosystem collapse and biofilter formation following seabed methane leakage

This study shows that seabed ecosystems rapidly collapse and form a methane biofilter after methane leakage from hydrates, with significant microbial and macrofaunal changes.

Morphological Identification of Ticks in district Swabi, Mardan, and Charsadda

This study identifies and maps tick species in Swabi, Mardan, and Charsadda districts, revealing morphological diversity and distribution patterns relevant to disease transmission.

Cholesterol esterification blockade boosts immunotherapy and reduces liver cancer relapse

This study identifies SOAT1 as a target for improving immunotherapy and reducing liver cancer relapse by blocking cholesterol esterification.

Microbial succession, community assembly and adaptation over five years in a newly discovered deep-sea cold seep

This study tracks microbial succession, community assembly, and adaptation over five years at a deep-sea cold seep, revealing shifts in community structure and functional adaptations.

A new yeast-based bioreporter for simple, sensitive, and cost-effective detection of dioxin-like compounds

This study develops a yeast-based bioreporter, DnaSc, for sensitive and cost-effective detection of dioxin-like compounds and AhR agonists with a detection limit of 10 fM for TCDD.

Inference of disease-associated microbial gene modules based on metagenomic and metatranscriptomic data

This paper introduces IDAM, a method for inferring disease-associated microbial gene modules from metagenomic and metatranscriptomic data, showing superior performance and reproducibility in inflammatory bowel disease datasets.

Whole exome sequencing identifies genes associated with non-obstructive azoospermia

The paper identifies five novel genes associated with non-obstructive azoospermia through whole exome sequencing and linkage analysis in a case-control study.

DNB-Based On-Chip Motif Finding (DocMF): a High-Throughput Method to Profile Different Types of Protein-DNA Interactions

The paper introduces DocMF, a high-throughput method to profile protein-DNA interactions, identifying PAM sequences for CRISPR systems and other DNA-binding proteins.

Advanced Whole Genome Sequencing Using an Entirely PCR-free Massively Parallel Sequencing Workflow

This paper demonstrates that PCR-free whole genome sequencing using the DNBSEQ platform and machine learning variant calling significantly reduces InDel errors and improves variant calling performance.