Response of UBR-box E3 ubiquitin ligases and protein quality control pathways to perturbations in protein synthesis and skeletal muscle size
Leslie M. Baehr, Luís Gustavo Oliveira de Sousa, Craig A. Goodman, Adam Philip Sharples, David S. Waddell, Sue C. Bodine, David C. Hughes
This study investigates how UBR-box E3 ubiquitin ligases respond to changes in protein synthesis and skeletal muscle size, finding increased abundance and activity of these ligases under conditions of muscle growth and regeneration.
American Journal of Physiology-Cell Physiology · Oct 14, 2025Peer-reviewedPhysiology