Timothy J. Knowles

This study identifies PqiABC as a membrane-bridging conduit that facilitates bidirectional phospholipid transport between inner and outer membranes in Gram-negative bacteria.

This paper characterizes TipA and TipB, two proteins from Bdellovibrio bacteriovorus, showing TipA's lipid-binding structure and TipB's role in inducing conformational changes in TipA.

This study identifies UBE2 family members that interact with MuRF1 to mediate ubiquitylation, revealing a two-step mechanism for mono- and poly-ubiquitin chain formation.

This study shows that SAE2 deacetylation during mitosis biases SUMO2 over SUMO1 conjugation, affecting mitotic fidelity through SUMOylation of NuMA.

This study identifies MlaFEDB as a flippase that uses ATP hydrolysis to transport phospholipids between membrane leaflets and shows ATP-independent phospholipid loading into MlaC.

The paper solves the crystal structure of MlaC and shows the Mla pathway exports phospholipids from the inner membrane to the periplasm, challenging the previous belief in retrograde transport.