BiophysicsProceedings of the National Academy of SciencesPeer-reviewed
Differential Roles of Kinetic On- and Off-Rates in T-Cell Receptor Signal Integration Revealed with a Modified Fab'-DNA Ligand
Kiera B. Wilhelm, Anand Vissa, Jay T. Groves
This paper introduces a modified Fab'-DNA ligand to study TCR signal integration by controlling kinetic on- and off-rates, revealing how dwell time affects TCR signaling and LAT condensation.
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