Human brain-derived Aβ oligomers bind to synapses and disrupt synaptic activity in a manner that requires APP
Zemin Wang, Rosemary J. Jackson, Wei Hong, Walter M. Taylor, Grant T. Corbett, Arturo J. Moreno, Wen Liu, Shaomin Li, Matthew P. Frosch, Inna Slutsky, Tracy L. Young‐Pearse, Tara L. Spires‐Jones, Dominic M. Walsh
The paper shows that Aβ oligomers from AD brain bind to synapses and disrupt synaptic activity, and this requires APP.
Journal of Neuroscience · Nov 3, 2017Peer-reviewedNeuroscience