Rosemary J. Jackson

The paper develops BiTSA, a bioluminescence-based thermal stability assay, to characterize isoform-dependent thermal stability of ApoE variants in living cells and confirms that ApoE4 is less stable than ApoE3 in native tissue.

The paper shows lipidated ApoE is closely located to Aβ aggregates in human Alzheimer's brains, suggesting a role in plaque formation.

This paper shows that APOE2 gene therapy reduces amyloid deposition, neurodegeneration, and microglial activation in an Alzheimer's mouse model with ongoing APOE4 expression.

The paper identifies transmembrane protein 97 as a synaptic receptor for amyloid beta in human Alzheimer's disease using advanced microscopy and drug intervention studies.

The paper identifies over 5,500 synaptic proteins in Alzheimer’s disease and controls, revealing APOE4-associated changes in synaptic and mitochondrial function and neuroimmune signaling.

This study shows that reducing tau improves behavioural and transcriptional issues in a mouse model of Alzheimer’s disease, suggesting synaptic tau reduction could be a therapeutic strategy.

The paper shows that Aβ oligomers from AD brain bind to synapses and disrupt synaptic activity, and this requires APP.