Author

Morito Sakuma

University of British ColumbiaORCID 0000-0002-8804-9831Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:simulation· 1

Frequent Co-Authors

Nobuhiko TokurikiiD· 2 shared Colin J. JacksoniD· 1 shared Dhani Ram MahatoiD· 1 shared Eiji NakataiD· 1 shared Ferran FeixasiD· 1 shared John Z. CheniD· 1 shared Naoki KonnoiD· 1 shared Sevan Gholipour· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 21 mutual co-author links

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2 shared papersBiochemistry

Nobuhiko TokurikiORCID

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2 papers

Recent·Most cited

Single-Molecule Kinetic Exploration of Functional Substates in an Evolving Phosphotriesterase

Morito Sakuma, Dhani Ram Mahato, Ferran Feixas, Colin J. Jackson, Eiji Nakata, Sílvia Osuna, Nobuhiko Tokuriki

This study investigates how functional and conformational substates change during enzyme evolution using single-molecule kinetic assays and simulations, showing coordinated shifts in substate equilibria that optimize catalytic efficiency.

Nature Communications · May 2, 2026Peer-reviewedBiochemistry

Widespread promiscuous alkaline phosphatases underscore early microbial phosphite utilization

Morito Sakuma, Naoki Konno, Sevan Gholipour, John Z. Chen, Nobuhiko Tokuriki

The paper identifies alkaline phosphatase (AP) as a widespread promiscuous enzyme capable of oxidizing phosphite, contributing to microbial phosphorus cycling.

bioRxiv · Apr 29, 2025 · PreprintBiochemistry