John Z. Chen

The paper maps the global distribution of β-lactamases across environments and microbes, revealing their abundance and potential origins in plant and wastewater ecosystems.

This study maps the sequence space of bacterial chitinases to show how domain composition and catalytic core evolve differently based on functional roles.

The paper presents analyses to assess selection dynamics in multi-round protein selection experiments, offering insights into diversity, coverage, and reproducibility.

The paper introduces a sequence analysis pipeline that improves exploration of protein sequence space through hierarchical clustering and alternative homology metrics, demonstrating scalability and utility in analyzing large datasets.

The paper identifies alkaline phosphatase (AP) as a widespread promiscuous enzyme capable of oxidizing phosphite, contributing to microbial phosphorus cycling.