Erfan Bahramnejad

A De Novo, Intragenic Modifier in Cis Rescues Scn8a-N1768D Epilepsy and Defines a Therapeutic Window Bounded by Gain- and Loss-of-Function

The paper identifies a de novo frameshift variant that rescues a Gain-of-function SCN8A epilepsy phenotype by reducing NaV1.6 expression within a therapeutic window.

Cis-Attenuation of Pathogenic Scn8a Variant Causing Childhood Epilepsy Reveals Opposing Transcriptional Programs Driving NaV1.6 Gain and Loss of Function Phenotypes

The paper identifies opposing transcriptional programs in SCN8A-related epilepsy, showing distinct cellular responses to gain- and loss-of-function mutations and suggesting therapeutic strategies.

Molecular Dynamics in the Ventral Tegmental Area during Chronic Pain-Induced Negative Affect

This study investigates molecular changes in the ventral tegmental area of mice with chronic pain-induced negative affect, identifying sex-dependent Kv7.2 channel expression and endocannabinoid level alterations.