Paul R. Langlais

The paper uses SEC-MS with crosslinking to analyze global changes in subcellular structures in Ewing sarcoma cell lines and after drug treatment, identifying effects on splicing, mitochondria, nucleoli, and peroxisomes.

The paper identifies MARPs as key modulators of titin-based mechanotransduction and shows mTORC1 regulates longitudinal muscle hypertrophy in response to stretch.

This study shows Akt1 nitration promotes PAH by enhancing EndMT and vascular proliferation, using a nitration-resistant mouse model.

This paper elucidates how Gtr1/2 and Pib2 regulate TORC1 in budding yeast through distinct signaling states under different nutrient conditions.

This study investigates molecular changes in the ventral tegmental area of mice with chronic pain-induced negative affect, identifying sex-dependent Kv7.2 channel expression and endocannabinoid level alterations.

This study identifies TMEM184B as a regulator of endolysosomal acidification in neurons by promoting V-ATPase assembly, linking it to neuronal function and disorders.

The paper analyzes PKA signaling in yeast using phosphoproteomics to show how different cAMP concentrations and conditions affect phosphorylation thresholds and growth states.