This study investigates proteomic changes in glioblastoma cells treated with HeberFERON compared to individual IFNs, identifying multitarget effects and potential pharmacodynamic biomarkers.

bioRxiv · Apr 24, 2026 · PreprintCancer Biology

LC-MS/MS characterization of SOBERANA(R)02, a receptor binding domain-tetanus toxoid conjugate vaccine against SARS-CoV-2

Olivia Martínez, Darielys Santana-Mederos, Satomy Pousa, Jean Pierre Soubal, Arielis Rodríguez‐Ulloa, Pablo E. Ramos‐Bermúdez, Vladimir Besada, Raine Garrido, Paulo C. Carvalho, Michel Batista, Katharina Zetl, Jacek R. Wiśniewski, Tammy Boggiano-Ayo, Yury Valdés-Balbín, Dagmar García-Rivera, , Luis Javier González

This paper characterizes the conjugation sites of a SARS-CoV-2 vaccine using LC-MS/MS and identifies 12 and 18 conjugation sites through different analytical strategies.

PROTEOMICS · Jul 1, 2025Peer-reviewedBiochemistry

Time- and Dose-dependent Effects of CIGB-300 in the lung squamous cell carcinoma proteomics.

Liudy García Hernández, Lingfeng Dai, Arielis Rodríguez‐Ulloa, Ying Yi, Luis Javier González, Vladimir Besada, Wen Li, Yasser Perera

This study examines the time- and dose-dependent effects of CIGB-300 on the proteome of squamous lung cancer cells, identifying potential biomarkers and mechanisms of action.

Biological Chemistry · Mar 1, 2025Peer-reviewedCancer Biology

Structural and Functional Glycosylation of the Abdala COVID-19 Vaccine

Sean Anthony Burnap, Valeria Calvaresi, Gleysin Cabrera, Satomy Pousa, Miladys Limonta Fernández, Yassel Ramos, Luis Javier González, David John Harvey, Weston B. Struwe

This study characterizes the N-glycan structures and their impact on the structural dynamics and functional properties of the Abdala COVID-19 vaccine.

Glycobiology · Jan 10, 2025Peer-reviewedBiochemistry