Increased versican and fibrosis in mesenteric lymph nodes disrupts immune surveillance and drives systemic bacterial dissemination in cirrhosis
Pinky Juneja, Aarti Sharma, Deepika Jakhar, Bhaskar Sharma, Ashwini Vasudevan, Simran Sharma, Dinesh Mani Tripathi, Vikas Khillan, Amar Mukund, Guresh Kumar, Shiv Kumar Sarin, Savneet Kaur
This study identifies increased versican and fibrosis in mesenteric lymph nodes as drivers of immune suppression and systemic bacterial dissemination in cirrhosis, with plasma versican levels serving as a prognostic biomarker for sepsis-related mortality.
Journal of Clinical and Experimental Hepatology · Jan 1, 2025Peer-reviewedPhysiology