Shiv Kumar Sarin

The paper isolates and characterizes extracellular vesicles from four edible plants, identifies source-specific phytometabolites, and demonstrates distinct functional properties in cell models.

This study profiles the metabolome of Ashwagandha to identify bioactive compounds and their associations with therapeutic functions.

This study identifies Wnt7a as a lymphangiocrine factor that promotes cholangiocyte proliferation during liver regeneration in both rodent and human models.

The paper identifies Streptococcal Scl1 as a bacterial protein that activates TGFβR1 signaling, driving fibrosis-inflammation in alcohol-associated liver disease through gut microbiota alterations.

The paper identifies PS1145 as a potential therapeutic for reducing systemic inflammation in alcohol-related liver disease by inhibiting IKK phosphorylation and TLR dimerization.

This study identifies elevated chenodeoxycholic acid as a poor prognostic marker in acute liver failure and shows that Bacteroides intestinalis-AM1 reduces bile acids and inflammation, improving liver injury.

This study identifies increased versican and fibrosis in mesenteric lymph nodes as drivers of immune suppression and systemic bacterial dissemination in cirrhosis, with plasma versican levels serving as a prognostic biomarker for sepsis-related mortality.

This study uses multi-omics analysis to show aspirin reduces liver fibrosis in mice by altering proteome, metabolome, and microbiome pathways linked to inflammation and oxidative stress.