Cancer BiologybioRxivPreprint
Fanconi Anaemia E3 Ligase complex activity is regulated by a druggable metabolite binding site in FANCX
Michael F. Sharp, Yi Sing Gee, Jennii Luu…·Wayne Crismani
The paper identifies a druggable metabolite binding site in the FA E3 ligase complex that inhibits its activity and selectively kills BRCA1-deficient cells.
DOI 10.64898/2026.08.07.743451