Author

Henry G. Beetham

Peter MacCallum Cancer CentreORCID 0000-0002-8446-2485Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Andrew J. DeansiD· 1 shared Christopher G. LangendorfiD· 1 shared Daqing Che· 1 shared Debora CaveroiD· 1 shared Jennii LuuiD· 1 shared John W. ScottiD· 1 shared Jonathan B. BaelliD· 1 shared Jonathan S. OakhilliD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Andrew J. DeansORCID

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1 paper

Recent·Most cited

Fanconi Anaemia E3 Ligase complex activity is regulated by a druggable metabolite binding site in FANCX

Michael F. Sharp, Yi Sing Gee, Jennii Luu, Karla J. Cowley, Henry G. Beetham, Christopher G. Langendorf, Jonathan S. Oakhill, John W. Scott, Debora Cavero, Jordi Minguillón, Daqing Che, Jonathan B. Baell, Andrew J. Deans, Jordi Surrallés, Kaylene J. Simpson, Wayne Crismani

The paper identifies a druggable metabolite binding site in the FA E3 ligase complex that inhibits its activity and selectively kills BRCA1-deficient cells.

bioRxiv · Aug 7, 2026 · PreprintCancer Biology