John W. Scott

Fine tuning energy metabolism in skeletal muscle: Discovery of a novel autoinhibitory mechanism in the N-terminal extension of AMPKγ3

This study identifies an autoinhibitory mechanism in the N-terminal extension of AMPKγ3 that regulates basal activity in skeletal muscle, offering a target for T2DM therapies.

Fanconi Anaemia E3 Ligase complex activity is regulated by a druggable metabolite binding site in FANCX

The paper identifies a druggable metabolite binding site in the FA E3 ligase complex that inhibits its activity and selectively kills BRCA1-deficient cells.

Unconventional binding of Calmodulin to CHK2 kinase inhibits catalytic activity

The paper identifies an unconventional mechanism where Ca2+-CaM binds CHK2 kinase to inhibit its activity, contrasting with its typical role in promoting kinase activity.

Mechanism and cellular actions of the potent AMPK inhibitor BAY-3827

This paper describes the mechanism and cellular effects of the potent AMPK inhibitor BAY-3827, showing it selectively blocks AMPK-dependent functions.

PSKH1 kinase activity is differentially modulated via allosteric binding of Ca2+ sensor proteins

The paper identifies allosteric regulation of PSKH1 kinase activity by Ca2+ sensor proteins, showing both activation and suppression by different sensors.