Clonal expansion dictates the efficacy of mitochondrial lineage tracing in single cells
Xin Wang, Kun Wang, Weixing Zhang, Zhongjie Tang, Hao Zhang, Yuying Cheng, Da Zhou, Chao Zhang, Wen‐Zhao Zhong, Qing Ma, Jin Xu, Zheng Hu
The paper investigates the reliability of mitochondrial DNA variants as lineage markers, finding that most are pre-existing heteroplasmy rather than de novo mutations, and introduces a score to identify reliable markers.
Genome biology · Mar 25, 2025Peer-reviewedBioinformatics