Kun Wang

This study compares the genomic evolution of sporadic and hereditary colorectal precancers using single-crypt whole-genome sequencing, revealing distinct mutation patterns and evolutionary trajectories.

This study uses lineage tracing and single-cell analysis to show tumor plasticity precedes stable immune evasion, with AP-1 regulating EMT stabilization during immunotherapy.

The paper investigates the reliability of mitochondrial DNA variants as lineage markers, finding that most are pre-existing heteroplasmy rather than de novo mutations, and introduces a score to identify reliable markers.

scPhyloX infers tissue development and tumor evolution dynamics using single-cell phylogenetic trees, revealing novel insights into stem cell overshoot, hematopoietic progenitor clonal expansion, and colorectal tumor subclonal selection.

The paper introduces PhyloVelo, a method that uses monotonically expressed genes to reconstruct cell fate transitions, outperforming existing approaches in embryo development and tumor evolution analysis.