Chamith Y. Fonseka

SPP1hi macrophages in RA synovial fibrin deposits promote tissue hyperplasia.

The paper introduces scPOST, a tool for estimating statistical power in single-cell studies, and shows that larger sample sizes, reduced batch effects, and lower cell state variability increase power to detect clinically associated cell state shifts.

The paper introduces MASC, a method to identify disease-associated cell subsets in single-cell data, and finds an expanded Th1-skewed cytotoxic CD4+ T cell subset in rheumatoid arthritis.

The paper identifies a link between structural genomic disruptions near ultraconserved elements and neurodevelopmental phenotypes.